New cytotoxic-antineoplastic prenyl-1,2-naphthohydroquinone derivatives

Bioorg Med Chem. 2005 Dec 15;13(24):6645-50. doi: 10.1016/j.bmc.2005.07.042. Epub 2005 Sep 16.

Abstract

Several new prenylnaphthohydroquinone derivatives have been prepared through the Diels-Alder condensation between alpha-myrcene and 1,2-benzoquinone and evaluated for their cytotoxic activity against A-549, HT-29 and MB-231 cultured cell lines. All of them have shown GI50 values in the microM level.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / toxicity*
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Humans
  • Inhibitory Concentration 50
  • Isomerism
  • Molecular Structure
  • Naphthoquinones / chemical synthesis
  • Naphthoquinones / chemistry*
  • Naphthoquinones / toxicity*
  • Prenylamine / analogs & derivatives*
  • Prenylamine / chemical synthesis
  • Prenylamine / chemistry
  • Prenylamine / toxicity

Substances

  • Antineoplastic Agents
  • Naphthoquinones
  • prenyl-1,2-naphthohydroquinone
  • Prenylamine