Synthesis and anthelmintic properties of arylquinolines with activity against drug-resistant nematodes

Bioorg Med Chem Lett. 2005 Nov 1;15(21):4806-8. doi: 10.1016/j.bmcl.2005.07.044.

Abstract

2,4-Disubstituted quinolines with additional substituents in positions 5-8 have been found to have anthelmintic properties. A number of 2,4-dimethoxy-6- or 8-arylquinolines have potent activity against the sheep nematode Haemonchus contortus, with LD99 values of the same order of magnitude as levamisole. These arylquinolines maintain their activity against levamisole-, ivermectin- and thiabendazole-resistant strains of H. contortus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anthelmintics / chemical synthesis*
  • Anthelmintics / pharmacology
  • Antinematodal Agents / chemical synthesis
  • Antinematodal Agents / pharmacology
  • Drug Resistance
  • Haemonchiasis / drug therapy
  • Haemonchiasis / veterinary
  • Nematoda / drug effects*
  • Quinolines / chemical synthesis*
  • Quinolines / pharmacology
  • Sheep / parasitology
  • Structure-Activity Relationship

Substances

  • Anthelmintics
  • Antinematodal Agents
  • Quinolines