Abstract
A nine-step synthesis of trans 4-cyclohexyl-L-proline has been developed on a laboratory scale. The product is an intermediate in the preparation of fosinopril--an effective hypotensive drug. The total yield of the synthesis was 25%. The final product was 99.7% pure. Analytical methods were developed for each step of the synthesis (HPLC, TLC, IR, 1H-NMR, 13C-NMR, GC-MS, [alpha]D).
MeSH terms
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Antihypertensive Agents / analysis
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Antihypertensive Agents / chemical synthesis
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Antihypertensive Agents / metabolism
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Chromatography, High Pressure Liquid
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Chromatography, Thin Layer
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Fosinopril / analysis
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Fosinopril / chemical synthesis*
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Fosinopril / metabolism
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Gas Chromatography-Mass Spectrometry
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Magnetic Resonance Spectroscopy
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Optical Rotation
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Proline / chemical synthesis*
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Proline / chemistry
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Proline / metabolism
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Technology, Pharmaceutical / methods
Substances
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Antihypertensive Agents
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Proline
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Fosinopril