Abstract
Meningeal melanocytoma refers to the uncommon clinical appearance of a generally benign tumour deriving from leptomeningeal melanocytes. Meningeal spread of this tumour is very rarely observed. We present the case of a 38-year-old man with meningeal melanocytoma of the cerebello-pontine angle, who showed a biphasic course of this disease, with a stable period followed by a steady progress within few months. After surgical resection of the melancytoma in the left skull base and of a first local recurrence five years later, a second local recurrence occurred 6 years after diagnosis, with intracerebral and spinal meningeal seeding. This tumor did not respond to a combined radiochemotherapy including oral temozolomide, and the patient died 5 months after starting treatment for this relapse. Secondary malignisation of the melancytoma is suggested.
MeSH terms
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Administration, Oral
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Adult
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Antineoplastic Agents, Alkylating / administration & dosage
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Antineoplastic Agents, Alkylating / therapeutic use
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Arachnoid
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Cerebellar Diseases / diagnosis
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Cerebellar Neoplasms / diagnosis
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Cerebellopontine Angle*
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Combined Modality Therapy
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Dacarbazine / analogs & derivatives
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Dacarbazine / therapeutic use
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Diagnosis, Differential
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Disease Progression
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Humans
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Magnetic Resonance Imaging
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Male
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Melanocytes / pathology*
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Melanoma* / diagnosis
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Melanoma* / pathology
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Meningeal Neoplasms* / diagnosis
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Meningeal Neoplasms* / drug therapy
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Meningeal Neoplasms* / mortality
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Meningeal Neoplasms* / pathology
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Meningeal Neoplasms* / radiotherapy
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Meningeal Neoplasms* / surgery
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Meninges*
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Neoplasm Recurrence, Local
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Neoplasm Seeding*
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Pia Mater
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Radiotherapy Dosage
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Temozolomide
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Time Factors
Substances
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Antineoplastic Agents, Alkylating
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Dacarbazine
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Temozolomide