A de novo designed inhibitor of D-Ala-D-Ala ligase from E. coli

Angew Chem Int Ed Engl. 2005 Oct 7;44(39):6403-6. doi: 10.1002/anie.200501662.
No abstract available

MeSH terms

  • Binding Sites
  • Crystallography, X-Ray
  • Cyclopropanes / chemical synthesis
  • Cyclopropanes / chemistry
  • Cyclopropanes / pharmacology*
  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology*
  • Escherichia coli / enzymology*
  • Models, Molecular
  • Molecular Conformation
  • Peptide Synthases / antagonists & inhibitors*
  • Protein Conformation
  • Software
  • Structure-Activity Relationship

Substances

  • Cyclopropanes
  • Enzyme Inhibitors
  • cyclopropane
  • Peptide Synthases
  • D-alanylalanine synthetase