Abstract
We report a 12-year study of a family with high mortality rate due to primary generalized epilepsy. During indicated and non-indicated therapy with anticonvulsive drugs (succinimides and hydantoines) there developed symptoms of systematic lupus erythematosus. The value of controlled immunological and genetic markers is discussed.
MeSH terms
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Adolescent
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Adult
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Anticonvulsants / adverse effects*
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Anticonvulsants / therapeutic use
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Child
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Electroencephalography
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Epilepsy, Generalized / drug therapy
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Epilepsy, Generalized / genetics*
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Female
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HLA Antigens / genetics
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Humans
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Lupus Erythematosus, Systemic / chemically induced*
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Lupus Erythematosus, Systemic / genetics
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Male
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Pedigree
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Phenotype
Substances
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Anticonvulsants
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HLA Antigens