[Familial primary generalized epilepsy and drug (anticonvulsant)-induced systemic lupus erythematosus--a family study]

Z Rheumatol. 1992 Mar-Apr;51(2):65-77.
[Article in German]

Abstract

We report a 12-year study of a family with high mortality rate due to primary generalized epilepsy. During indicated and non-indicated therapy with anticonvulsive drugs (succinimides and hydantoines) there developed symptoms of systematic lupus erythematosus. The value of controlled immunological and genetic markers is discussed.

Publication types

  • English Abstract

MeSH terms

  • Adolescent
  • Adult
  • Anticonvulsants / adverse effects*
  • Anticonvulsants / therapeutic use
  • Child
  • Electroencephalography
  • Epilepsy, Generalized / drug therapy
  • Epilepsy, Generalized / genetics*
  • Female
  • HLA Antigens / genetics
  • Humans
  • Lupus Erythematosus, Systemic / chemically induced*
  • Lupus Erythematosus, Systemic / genetics
  • Male
  • Pedigree
  • Phenotype

Substances

  • Anticonvulsants
  • HLA Antigens