Abstract
Circumdatin H (1), a new alkaloid from the culture broth of Aspergillus ochraceus, has been isolated, together with a known circumdatin, circumdatin E (2) and other known compounds: flavacol (3) and stephacidin A (4). The structure of 1 was established on the basis of chemical and spectral evidence. All of these alkaloids showed biological activity as inhibitors of the mammalian mitochondrial respiratory chain.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aspergillus ochraceus / metabolism*
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Benzodiazepinones / isolation & purification
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Benzodiazepinones / pharmacology*
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Chemical Phenomena
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Chemistry, Physical
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Electron Transport / drug effects
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Enzyme Inhibitors / isolation & purification
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Enzyme Inhibitors / pharmacology*
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Fermentation
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Mitochondria / drug effects
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Mitochondria / enzymology*
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Multienzyme Complexes / antagonists & inhibitors*
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NADH, NADPH Oxidoreductases / antagonists & inhibitors*
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Spectrophotometry, Infrared
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Spectrophotometry, Ultraviolet
Substances
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Benzodiazepinones
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Enzyme Inhibitors
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Multienzyme Complexes
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circumdatin H
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NADH oxidase
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NADH, NADPH Oxidoreductases