Circumdatin H, a new inhibitor of mitochondrial NADH oxidase, from Aspergillus ochraceus

J Antibiot (Tokyo). 2005 Jun;58(6):416-9. doi: 10.1038/ja.2005.54.

Abstract

Circumdatin H (1), a new alkaloid from the culture broth of Aspergillus ochraceus, has been isolated, together with a known circumdatin, circumdatin E (2) and other known compounds: flavacol (3) and stephacidin A (4). The structure of 1 was established on the basis of chemical and spectral evidence. All of these alkaloids showed biological activity as inhibitors of the mammalian mitochondrial respiratory chain.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aspergillus ochraceus / metabolism*
  • Benzodiazepinones / isolation & purification
  • Benzodiazepinones / pharmacology*
  • Chemical Phenomena
  • Chemistry, Physical
  • Electron Transport / drug effects
  • Enzyme Inhibitors / isolation & purification
  • Enzyme Inhibitors / pharmacology*
  • Fermentation
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Mitochondria / drug effects
  • Mitochondria / enzymology*
  • Multienzyme Complexes / antagonists & inhibitors*
  • NADH, NADPH Oxidoreductases / antagonists & inhibitors*
  • Spectrophotometry, Infrared
  • Spectrophotometry, Ultraviolet

Substances

  • Benzodiazepinones
  • Enzyme Inhibitors
  • Multienzyme Complexes
  • circumdatin H
  • NADH oxidase
  • NADH, NADPH Oxidoreductases