Methicillin-resistant Staphylococcus aureus (MRSA) often acquires multi-drug resistance and is involved in many cases of disease in hospitals. We investigated natural substances directly effective against MRSA or that influence antibiotic resistance. Aloe-emodin, an anthraquinone, and several licorice flavonoids showed potent antibacterial effects against MRSA. Like some hydrolysable tannins (corilagin and tellimagrandin I) and a tea polyphenol [(-)-epicatechin gallate], the licorice flavonoid licoricidin also restored the effects of oxacillin, a beta-lactam antibiotic against MRSA. Further study revealed that theasinensin A, a polyphenol formed from (-)-epigallocatechin gallate, proanthocyanidins obtained from fruits of Zizyphus jujuba var. inermis, and polymeric proanthocyanidins from fruit peels of Zanthoxylum piperitum also suppressed the antibiotic resistance of MRSA.