We describe the technique of partial liquid ventilation and outline its indications. We present our imaging experience with this infrequently used therapy using a wide variety of radiographs from neonatal and adult patients. The radiographic appearance of white lungs, due to the perfluorocarbons used in partial liquid ventilation, may initially be rather perplexing, but can be an advantage in diagnosing certain complications of mechanical ventilation, outlining pathology and demonstrating normal anatomy in an unusual manner.