Evaluation of adverse effects in intracarotid propofol injection for Wada test

Neurology. 2005 Dec 13;65(11):1813-6. doi: 10.1212/01.wnl.0000176988.87336.ff. Epub 2005 Sep 7.

Abstract

The authors evaluated adverse effects of intracarotid propofol injection during a Wada test and their risk factors in 58 patients. Nineteen patients had an adverse effect, mostly in patients receiving more than 10 mg. For patients older than age 55 years or those requiring an injection dose greater than 20 mg to produce hemiplegia, propofol should be injected slowly and patients monitored for excitatory movements.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Anesthetics, Intravenous / adverse effects
  • Cerebral Cortex / drug effects*
  • Cerebral Cortex / physiology
  • Cerebral Cortex / surgery
  • Child
  • Dose-Response Relationship, Drug
  • Dyskinesia, Drug-Induced / prevention & control
  • Female
  • Functional Laterality / drug effects
  • Functional Laterality / physiology
  • Humans
  • Injections, Intra-Arterial / adverse effects
  • Male
  • Memory / drug effects
  • Memory / physiology
  • Middle Aged
  • Postoperative Complications / physiopathology
  • Postoperative Complications / prevention & control*
  • Preoperative Care / adverse effects*
  • Propofol / adverse effects*
  • Retrospective Studies
  • Risk Factors
  • Speech / drug effects
  • Speech / physiology

Substances

  • Anesthetics, Intravenous
  • Propofol