Abstract
Critical to the development of an effective HIV vaccine is the identification of adaptive immune responses that prevent infection or disease. In this study we demonstrate in a relevant nonhuman primate model of AIDS that the magnitude of vaccine-induced virus-specific CD8(+) central memory T cells (T(CM)), but not that of CD8(+) effector memory T cells, inversely correlates with the level of SIVmac251 replication, suggesting their pivotal role in the control of viral replication. We propose that effective preventive or therapeutic T cell vaccines for HIV-1 should induce long-term protective central memory T cells.
MeSH terms
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Animals
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CD8-Positive T-Lymphocytes / immunology*
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Gene Products, gag / administration & dosage
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Gene Products, gag / immunology
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Immunity, Cellular / drug effects
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Immunodominant Epitopes / administration & dosage
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Immunodominant Epitopes / immunology
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Immunologic Memory* / drug effects
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Immunophenotyping
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Macaca
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SAIDS Vaccines / administration & dosage
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SAIDS Vaccines / pharmacology*
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Simian Acquired Immunodeficiency Syndrome / therapy*
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Simian Immunodeficiency Virus / drug effects
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Viremia / drug therapy
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Virus Replication / drug effects
Substances
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Gene Products, gag
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Immunodominant Epitopes
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SAIDS Vaccines