Use of proteomic patterns as a novel screening tool in pre-eclampsia

Jenny Myers; Maureen Macleod; B Reed; N Harris; G Mires; P Baker

doi:10.1080/01443610400018791

Use of proteomic patterns as a novel screening tool in pre-eclampsia

J Obstet Gynaecol. 2004 Nov;24(8):873-4. doi: 10.1080/01443610400018791.

Authors

Jenny Myers¹, Maureen Macleod, B Reed, N Harris, G Mires, P Baker

Affiliation

¹ Maternal and Fetal Health Research Centre, St Mary's Hospital, University of Manchester, Manchester, UK. jenny.myers@man.ac.uk

PMID: 16147639
DOI: 10.1080/01443610400018791

Abstract

This pilot study aimed to use Ciphergen ProteinChip technology to determine differences in protein profiles in plasma, taken at 26 weeks, from women at risk of developing pre-eclampsia. Five proteins were found to be significantly up-regulated in samples from women who subsequently developed pre-eclampsia compared with women who remained normotensive.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Blood Proteins / analysis*
Diagnosis*
Female
Gestational Age
Humans
Hydrogen-Ion Concentration
Mass Screening / methods*
Pre-Eclampsia
Pregnancy
Proteomics
Reproducibility of Results

Substances

Blood Proteins