Total synthesis of psammaplysenes A and B, naturally occurring inhibitors of FOXO1a nuclear export

Org Lett. 2005 Sep 15;7(19):4091-4. doi: 10.1021/ol0513286.

Abstract

[reaction: see text] Two inhibitors of FOXO1a-mediated nuclear export, psammaplysenes A and B, have been synthesized by a flexible and efficient route. A common starting material, 4-iodophenol, was used to prepare both halves of these pseudosymmetric dibromotyrosine-derived metabolites.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Active Transport, Cell Nucleus
  • Forkhead Transcription Factors / antagonists & inhibitors*
  • Forkhead Transcription Factors / metabolism*
  • Molecular Structure
  • Tyrosine / analogs & derivatives*
  • Tyrosine / chemical synthesis
  • Tyrosine / chemistry

Substances

  • Forkhead Transcription Factors
  • psammaplysene A
  • psammaplysene B
  • Tyrosine