Abstract
[reaction: see text] Two inhibitors of FOXO1a-mediated nuclear export, psammaplysenes A and B, have been synthesized by a flexible and efficient route. A common starting material, 4-iodophenol, was used to prepare both halves of these pseudosymmetric dibromotyrosine-derived metabolites.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Active Transport, Cell Nucleus
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Forkhead Transcription Factors / antagonists & inhibitors*
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Forkhead Transcription Factors / metabolism*
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Molecular Structure
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Tyrosine / analogs & derivatives*
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Tyrosine / chemical synthesis
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Tyrosine / chemistry
Substances
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Forkhead Transcription Factors
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psammaplysene A
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psammaplysene B
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Tyrosine