Abstract
The realization of cell replacement therapy derived from human pluripotent stem cells requires full knowledge of the starting cell types as well as their differentiated progeny. Alongside embryonic stem cells, embryonic germ cells (EGCs) are an alternative source of pluripotent stem cell. Since 1998, four groups have described the derivation of human EGCs. This review analyzes the progress on derivation, culture, and differentiation, drawing comparison with other pluripotent stem cell populations.
Publication types
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Evaluation Study
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Cell Culture Techniques / methods
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Cell Differentiation
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Cell Movement
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Cell Proliferation
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Cell- and Tissue-Based Therapy / methods
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Culture Media / chemistry
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Embryo, Mammalian / cytology*
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Embryo, Mammalian / physiology
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Gene Expression Profiling
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Gene Expression Regulation, Developmental
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Germ Cells / chemistry
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Germ Cells / physiology*
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Growth Substances / physiology
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Humans
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Mice
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Pluripotent Stem Cells / physiology*
Substances
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Culture Media
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Growth Substances