Sarcolobus globosus is a medicinal plant growing in mangrove forests in Asia. No constituents from this plant have been reported previously. From the diethyl ether extract of S. globosus a new rotenoid sarcolobin and a new isoflavone sarcolobone, as well as the previously known rotenoids tephrosin, 12aalpha-hydroxydeguelin, 11-hydroxytephrosin, 12a-hydroxyrotenone, 12aalpha-hydroxyrotenone, 6aalpha,12aalpha-12a-hydroxyelliptone, 6a,12a-dehydrodeguelin, 13- homo-13-oxa-6a,12a-dehydrodeguelin, the isoflavone barbigerone and a chromone 6,7-dimethoxy-2,3-dihydrochromone were identified. 6,7-Dimethoxy-2,3-dihydrochromone has not previously been reported as a natural product.