Abstract
Circadian rhythms of DNA synthesis, mitotic activity, and duration of mitosis in rat liver were studied on postnatal days 3, 7, and 12. Some age-related peculiarities of these rhythms were revealed. Epidermal growth factor was found to play an important role in the formation of cell proliferation rhythm during the early postnatal ontogeny and in the regulation of the pool of proliferating hepatocytes.
MeSH terms
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Animals
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Cell Proliferation / drug effects
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Circadian Rhythm / drug effects
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Circadian Rhythm / genetics
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Circadian Rhythm / physiology*
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DNA Replication / drug effects
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DNA Replication / physiology
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Epidermal Growth Factor / pharmacology
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Epidermal Growth Factor / physiology*
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Hepatocytes / cytology
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Hepatocytes / drug effects
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Hepatocytes / physiology*
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Liver / cytology
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Liver / growth & development*
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Mitosis / drug effects
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Mitosis / genetics
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Mitosis / physiology
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Rats
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Rats, Inbred Strains