Superparamagnetic nanoparticle-supported enzymatic resolution of racemic carboxylates

Hari M R Gardimalla; Deendayal Mandal; Philip D Stevens; Max Yen; Yong Gao

doi:10.1039/b504128g

Superparamagnetic nanoparticle-supported enzymatic resolution of racemic carboxylates

Chem Commun (Camb). 2005 Sep 21:(35):4432-4. doi: 10.1039/b504128g. Epub 2005 Aug 11.

Authors

Hari M R Gardimalla¹, Deendayal Mandal, Philip D Stevens, Max Yen, Yong Gao

Affiliation

¹ Department of Chemistry and Biochemistry, Mailcode 4409, Southern Illinois University, Carbondale, IL 62901-4409, USA.

PMID: 16136241
DOI: 10.1039/b504128g

Abstract

Candida rugosa lipase immobilized on maghemite nanoparticles demonstrated high stereoselectivity in kinetic resolution of racemic carboxylates and improved long-term stability over its parent free enzyme, allowing the supported enzyme to be repeatedly used for a series of chiral resolution reactions.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Candida / enzymology*
Carboxylic Acids / chemistry*
Enzymes, Immobilized / chemistry*
Ferric Compounds
Kinetics
Lipase / chemistry*
Nanostructures
Propionates / chemistry
Propionates / isolation & purification
Stereoisomerism

Substances

Carboxylic Acids
Enzymes, Immobilized
Ferric Compounds
Propionates
ferric oxide
Lipase
2-bromopropionic acid