The experience of artificial blood circulation application in 45 patients during surgical intervention performance for the pulmonary artery thromboembolism and vena cava inferior thrombosis was summarized. Peculiarities of the artificial blood circulation preparation and conduction were depicted and characteristic of the hemodynamics and oxygen metabolism indexes on various stages of operative treatment was presented. Analysis of results of treatment in patients after the operation was conducted. The efficacy of the operative treatment conduction was shown.