Linkage mapping of the carbonyl reductase (CBR) gene on human chromosome 21 using a DNA polymorphism in the 3' untranslated region

Genomics. 1992 Jun;13(2):447-8. doi: 10.1016/0888-7543(92)90268-w.

Abstract

A DNA polymorphism has been found in the 3' untranslated region of the carbonyl reductase gene (CBR). Genotypes of the members of the CEPH pedigrees have been obtained and used in linkage analysis to map the CBR gene in the linkage map of human chromosome 21. The gene maps between the interferon-alpha receptor (IFNAR) and the D21S55 loci.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alcohol Oxidoreductases / genetics*
  • Aldehyde Reductase
  • Aldo-Keto Reductases
  • Base Sequence
  • Chromosome Mapping
  • Chromosomes, Human, Pair 21*
  • DNA Mutational Analysis
  • Genes
  • Genotype
  • Humans
  • Lod Score
  • Molecular Sequence Data
  • Nucleic Acid Conformation
  • Polymerase Chain Reaction
  • Polymorphism, Genetic

Substances

  • Alcohol Oxidoreductases
  • Aldo-Keto Reductases
  • Aldehyde Reductase