Sodwanone S, a triterpene from the marine sponge Axinella weltneri

Corinne Funel-Le Bon; Fabrice Berrué; Olivier P Thomas; Fernando Reyes; Philippe Amade

doi:10.1021/np050100o

Sodwanone S, a triterpene from the marine sponge Axinella weltneri

J Nat Prod. 2005 Aug;68(8):1284-7. doi: 10.1021/np050100o.

Authors

Corinne Funel-Le Bon¹, Fabrice Berrué, Olivier P Thomas, Fernando Reyes, Philippe Amade

Affiliation

¹ Laboratoire de Chimie Bioorganique, UMR 6001 CNRS, Faculté des Sciences, UNSA, Parc Valrose, 06108 Nice Cedex 02, France.

PMID: 16124780
DOI: 10.1021/np050100o

Abstract

The bioassay-guided fractionation of the crude extract of the marine sponge Axinella weltneri led to the isolation and the identification of a new triterpene named sodwanone S (1), with an uncommon oxepane-cyclohexane system, along with the known sodwanones A and G. The structure was elucidated using spectroscopic data, and the biological activity was evaluated against 13 human tumor cell lines. A biogenetic pathway of this new compound is also proposed.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification*
Antineoplastic Agents / pharmacology
Drug Screening Assays, Antitumor
HeLa Cells
Humans
Inhibitory Concentration 50
Molecular Structure
Porifera / chemistry*
Triterpenes / chemistry
Triterpenes / isolation & purification*
Triterpenes / pharmacology
Tumor Cells, Cultured

Substances

Antineoplastic Agents
Triterpenes
sodwanone S