Abstract
Eli Lilly and Co is developing LY-544344, a prodrug of the metabotropic glutamate receptor 2/3 agonist LY-354740, for the potential treatment of anxiety disorders.
MeSH terms
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Alanine / analogs & derivatives
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Animals
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Anti-Anxiety Agents / chemical synthesis
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Anti-Anxiety Agents / metabolism
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Anti-Anxiety Agents / pharmacology
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Anti-Anxiety Agents / therapeutic use*
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Anxiety / drug therapy*
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Bridged Bicyclo Compounds / chemical synthesis
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Bridged Bicyclo Compounds / metabolism
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Bridged Bicyclo Compounds / pharmacology
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Bridged Bicyclo Compounds / therapeutic use*
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Clinical Trials as Topic
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Humans
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Prodrugs / therapeutic use*
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Receptors, Metabotropic Glutamate / agonists*
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Structure-Activity Relationship
Substances
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2-((2'-amino)propionyl)aminobicyclo(3.1.0)hexane-2,6-dicarboxylic acid
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Anti-Anxiety Agents
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Bridged Bicyclo Compounds
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Prodrugs
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Receptors, Metabotropic Glutamate
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metabotropic glutamate receptor 2
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metabotropic glutamate receptor 3
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Alanine
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eglumetad