LY-544344. Eli Lilly

IDrugs. 2005 Sep;8(9):755-62.

Abstract

Eli Lilly and Co is developing LY-544344, a prodrug of the metabotropic glutamate receptor 2/3 agonist LY-354740, for the potential treatment of anxiety disorders.

Publication types

  • Review

MeSH terms

  • Alanine / analogs & derivatives
  • Animals
  • Anti-Anxiety Agents / chemical synthesis
  • Anti-Anxiety Agents / metabolism
  • Anti-Anxiety Agents / pharmacology
  • Anti-Anxiety Agents / therapeutic use*
  • Anxiety / drug therapy*
  • Bridged Bicyclo Compounds / chemical synthesis
  • Bridged Bicyclo Compounds / metabolism
  • Bridged Bicyclo Compounds / pharmacology
  • Bridged Bicyclo Compounds / therapeutic use*
  • Clinical Trials as Topic
  • Humans
  • Prodrugs / therapeutic use*
  • Receptors, Metabotropic Glutamate / agonists*
  • Structure-Activity Relationship

Substances

  • 2-((2'-amino)propionyl)aminobicyclo(3.1.0)hexane-2,6-dicarboxylic acid
  • Anti-Anxiety Agents
  • Bridged Bicyclo Compounds
  • Prodrugs
  • Receptors, Metabotropic Glutamate
  • metabotropic glutamate receptor 2
  • metabotropic glutamate receptor 3
  • Alanine
  • eglumetad