Several new lyssaviruses have emerged in the past decade and it is likely that more remain to be discovered. There are six recognized genotypes of lyssavirus other than the rabies virus (genotype 1). All but one of these has been associated with human cases, with the resulting disease clinically similar to rabies. Rabies vaccines provide a means of pre- and postexposure prophylaxis against rabies and some of the other genotypes, but not all. Those that are crossprotected fall into phylogroup 1 of the genus, and those not protected in phylogroup 2. The crossprotection of phylogroup 1 viruses by rabies vaccines and the development of new, broader range or specific vaccines for phylogroup 2 viruses are reviewed.