Lipoxygenase inhibitory constituents from Indigofera oblongifolia

Arch Pharm Res. 2005 Jul;28(7):761-4. doi: 10.1007/BF02977339.

Abstract

Indigin, alkylated xanthene (1) and indigoferic acid (2) have been isolated from the chloroform soluble fraction of Indigofera oblongifolia, along with beta-sitosterol (3) and 3-hydroxybenzoic acid (4), which are reported for the first time from this species. Their structures were determined through spectroscopic techniques. Both the new compounds 1 and 2 showed significant activity against enzyme lipoxygenase, while 2 further showed moderate inhibition against BChE.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cholinesterase Inhibitors / isolation & purification
  • Cholinesterase Inhibitors / pharmacology
  • Cinnamates / isolation & purification*
  • Cinnamates / pharmacology
  • Fatty Acids / isolation & purification*
  • Fatty Acids / pharmacology
  • Hydroxybenzoates / isolation & purification
  • Indigofera / chemistry*
  • Inhibitory Concentration 50
  • Lipoxygenase Inhibitors / isolation & purification*
  • Lipoxygenase Inhibitors / pharmacology
  • Magnetic Resonance Spectroscopy
  • Plant Extracts / chemistry
  • Sitosterols / isolation & purification
  • Xanthenes / isolation & purification*
  • Xanthenes / pharmacology

Substances

  • Cholinesterase Inhibitors
  • Cinnamates
  • Fatty Acids
  • Hydroxybenzoates
  • Lipoxygenase Inhibitors
  • Plant Extracts
  • Sitosterols
  • Xanthenes
  • indigin
  • indigoferic acid
  • 3-hydroxybenzoic acid
  • gamma-sitosterol