The vicinal F-C-C-F moiety as a tool for influencing peptide conformation

Martin Schüler; David O'hagan; Alexandra M Z Slawin

doi:10.1039/b506010a

The vicinal F-C-C-F moiety as a tool for influencing peptide conformation

Chem Commun (Camb). 2005 Sep 14:(34):4324-6. doi: 10.1039/b506010a. Epub 2005 Jul 14.

Authors

Martin Schüler¹, David O'hagan, Alexandra M Z Slawin

Affiliation

¹ School of Chemistry and Centre for Biomolecular Sciences, University of St. Andrews, North Haugh, St. Andrews, Fife KY16 9ST, UK. do1@st-and.ac.uk

PMID: 16113736
DOI: 10.1039/b506010a

Abstract

Diastereoisomers of bis(amino acid amides) of 2,3-difluorosuccinic acid have been prepared and the erythro- and threo-isomers display very different conformations.

MeSH terms

Amino Acids / chemistry
Crystallography, X-Ray
Fluorine / chemistry
Indicators and Reagents
Models, Molecular
Peptides / chemistry*
Protein Conformation
Stereoisomerism

Substances

Amino Acids
Indicators and Reagents
Peptides
Fluorine