Dendritic supramolecular assemblies for drug delivery

Chem Commun (Camb). 2005 Sep 14:(34):4309-11. doi: 10.1039/b502411k. Epub 2005 Jul 14.

Abstract

Dendritic supramolecular assemblies were formed in water with Reichardt's dye or the anticancer drug 10-hydroxycamptothecin and the dendritic macromolecule, ([G4]-PGLSA-OH)2-PEG3400.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Antineoplastic Agents, Phytogenic / administration & dosage
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Camptothecin / administration & dosage
  • Camptothecin / analogs & derivatives
  • Camptothecin / pharmacology
  • Cell Survival / drug effects
  • Dendrimers / chemical synthesis*
  • Drug Delivery Systems*
  • Excipients / chemistry*
  • HT29 Cells
  • Humans
  • Irinotecan
  • Magnetic Resonance Spectroscopy
  • Molecular Conformation
  • Polyethylene Glycols / chemistry
  • Succinates / chemistry

Substances

  • ((G4)-PGLSA-OH)2-PEG3400 dendrimer
  • Antineoplastic Agents, Phytogenic
  • Dendrimers
  • Excipients
  • Succinates
  • Polyethylene Glycols
  • Irinotecan
  • Camptothecin