Zirconium mediated total synthesis of crinitol, 9-hydroxyfarnesoic acid, 9-hydroxyfarnesol, 9-hydroxysargaquinone and the selectively-protected aglycone of moritoside and euplexide A

Sally Dixon; George J Gordon; Richard J Whitby

doi:10.1039/b508524a

Zirconium mediated total synthesis of crinitol, 9-hydroxyfarnesoic acid, 9-hydroxyfarnesol, 9-hydroxysargaquinone and the selectively-protected aglycone of moritoside and euplexide A

Chem Commun (Camb). 2005 Sep 14:(34):4303-5. doi: 10.1039/b508524a. Epub 2005 Aug 5.

Authors

Sally Dixon¹, George J Gordon, Richard J Whitby

Affiliation

¹ School of Chemistry, University of Southampton, Highfield, Southampton, Hampshire SO17 1BJ, UK.

PMID: 16113729
DOI: 10.1039/b508524a

Abstract

Tandem formation of an unsaturated zirconacycle, insertion of methallyl carbenoid, and addition of an aldehyde provides a rapid synthetic route to several linear terpenoid and terpene-polyketide natural products.