Synthesis and cellular uptake of porphyrin decorated iron oxide nanoparticles-a potential candidate for bimodal anticancer therapy

Chem Commun (Camb). 2005 Sep 14:(34):4270-2. doi: 10.1039/b507779f. Epub 2005 Jul 14.

Abstract

This paper reports the synthesis, characterization, and cellular uptake of the conjugate of porphyrin and iron oxide nanoparticles, which may lead to a bimodal anticancer agent that can be used in the combinational treatment of photodynamic therapy (PDT) and hyperthermia therapy (HT).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / pharmacokinetics*
  • Ferric Compounds / chemistry*
  • HeLa Cells
  • Humans
  • Hyperthermia, Induced
  • Microscopy, Electron, Transmission
  • Nanoparticles*
  • Particle Size
  • Photochemotherapy
  • Porphyrins / chemical synthesis*
  • Porphyrins / pharmacokinetics*
  • Spectrometry, Fluorescence
  • Spectrophotometry, Ultraviolet

Substances

  • Antineoplastic Agents
  • Ferric Compounds
  • Porphyrins
  • ferric oxide