Part six of this series discusses established and emerging technologies in breast cancer care, with an emphasis on technologies in diagnosis and treatment supported by evidence. These include percutaneous core biopsy techniques and breast imaging in diagnosis. From the surgical perspective, we discuss the emerging role of sentinel node biopsy as a potentially less invasive method of staging the axilla in women with breast cancer. We also review advances in radiotherapy techniques that have allowed delivery of radiotherapy with more precision and improved safety.