Gene expression profile analysis of Porphyromonas gingivalis during invasion of human coronary artery endothelial cells

Infect Immun. 2005 Sep;73(9):6169-73. doi: 10.1128/IAI.73.9.6169-6173.2005.

Abstract

Microarrays were used to identify genes of Porphyromonas gingivalis W83 differentially expressed during invasion of primary human coronary artery endothelial cells. Analyses of microarray images indicated that 62 genes were differentially regulated. Of these, 11 genes were up-regulated and 51 were down-regulated. The differential expression of 16 selected genes was confirmed by real-time PCR.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Bacteroidaceae Infections / metabolism*
  • Cells, Cultured
  • Coronary Vessels / microbiology*
  • Down-Regulation / immunology
  • Endothelium, Vascular / cytology
  • Endothelium, Vascular / microbiology*
  • Gene Expression Profiling*
  • Gene Expression Regulation, Bacterial / immunology
  • Humans
  • Porphyromonas gingivalis / genetics*
  • Porphyromonas gingivalis / metabolism
  • Up-Regulation / immunology