Molarless-induced changes of spines in hippocampal region of SAMP8 mice

Kin-Ya Kubo; Fumihiko Iwaku; Kazuko Watanabe; Masafumi Fujita; Minoru Onozuka

doi:10.1016/j.brainres.2005.07.038

Molarless-induced changes of spines in hippocampal region of SAMP8 mice

Brain Res. 2005 Sep 28;1057(1-2):191-5. doi: 10.1016/j.brainres.2005.07.038.

Authors

Kin-Ya Kubo¹, Fumihiko Iwaku, Kazuko Watanabe, Masafumi Fujita, Minoru Onozuka

Affiliation

¹ Department of Oral Anatomy, Division of Oral Structure, Function and Development, Asahi University School of Dentistry, 1851 Hozumi, Mizuho, Gifu 501-0296, Japan. kubo@dent.asahi-u.ac.jp

PMID: 16112090
DOI: 10.1016/j.brainres.2005.07.038

Abstract

We examined the effect of the molarless condition on the dendritic spines of hippocampal pyramidal cells in SAMP8 mice in comparison to its effect on learning ability in a maze test. The molarless condition caused a decrease in the number of the spines of CA1 pyramidal cells only in the aged mice showing a reduced learning ability. The results suggest the involvement of the molarless condition in an attenuation of input activities in the hippocampal synapses.

Publication types

Comparative Study

MeSH terms

Age Factors
Aging* / genetics
Aging* / metabolism
Aging* / physiology
Analysis of Variance
Animals
Behavior, Animal
Dendritic Spines / physiology*
Dendritic Spines / ultrastructure
Hippocampus / cytology*
Male
Maze Learning / physiology
Mice
Molar / physiology*
Pyramidal Cells / physiology*
Pyramidal Cells / ultrastructure
Reaction Time
Silver Staining / methods
Time Factors