Abstract
Currently 4% of the Danish national birth cohort is born after in vitro fertilisation techniques and almost 40% of these children are twins. In this register-based national cohort study, twins from assisted conception (n = 3393) had a similar risk of neurological sequelae and cerebral palsy as their naturally conceived peers (n = 10.239) and assisted conceived singletons (n = 5130). Further children born after intracytoplasmic sperm injection (ICSI) had the same risk of neurological sequelae as children born after conventional IVF.
MeSH terms
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Adult
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Cerebral Palsy / epidemiology
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Cerebral Palsy / etiology
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Child
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Child, Preschool
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Cohort Studies
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Denmark / epidemiology
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Diseases in Twins / epidemiology
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Diseases in Twins / etiology*
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Female
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Fertilization in Vitro / adverse effects*
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Follow-Up Studies
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Humans
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Intellectual Disability / epidemiology
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Intellectual Disability / etiology
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Male
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Maternal Age
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Nervous System Diseases / epidemiology
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Nervous System Diseases / etiology*
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Pregnancy
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Pregnancy, Multiple
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Psychomotor Disorders / epidemiology
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Psychomotor Disorders / etiology
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Registries
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Risk Factors
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Sperm Injections, Intracytoplasmic / adverse effects*
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Twins