Indole-5-phenylcarbamate derivatives as human non-pancreatic secretory phospholipase A2 inhibitor

Bioorg Med Chem Lett. 2005 Oct 15;15(20):4540-2. doi: 10.1016/j.bmcl.2005.07.006.

Authors

Ying Liu¹, Xiao-feng Han, Chang-kang Huang, Xin Hao, Lu-Hua Lai

Affiliation

¹ State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Institute of Physical Chemistry and College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China. liuying@pku.edu.cn

PMID: 16105733
DOI: 10.1016/j.bmcl.2005.07.006

Abstract

The synthesis of the human non-pancreatic secretory phospholipase A2 inhibitor (IC(50)=1.81+/-0.59 microM) is reported.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Group II Phospholipases A2
Humans
Kinetics
Models, Molecular
Phenylcarbamates / chemistry
Phenylcarbamates / pharmacology*
Phospholipases A / antagonists & inhibitors*
Phospholipases A2
Spectrometry, Fluorescence

Substances

Phenylcarbamates
Phospholipases A
Group II Phospholipases A2
Phospholipases A2