Clinical manifestations of chronic viral hepatitis B (CVH-B) in replicative phase in patients with superinvasive opisthorchosis comprise the asthenic-vegetative syndrome, pain syndrome, dyspepsia (53.3% of cases) and hepatomegaly (46.7% of cases). Superinvasive opisthorchosis, when combined with CVH-B, stimulates the cytolysis of hepatocytes and the intensity of inflammation; it also shapes the fibrosis of the liver, which complicates the course of viral infection and its outcome.