The first synthesis of chiral PNA monomer-cyclen conjugates

J Pept Sci. 2005 Dec;11(12):812-7. doi: 10.1002/psc.685.

Abstract

A synthetic route to novel chiral PNA monomer-cyclen conjugates was described for the first time, the targeted products were obtained in high yields under mild reaction conditions. The preliminary results demonstrated that the uracil-PNA monomer-cyclen conjugates can rapidly bind Zn2+ in aqueous solution, and the structure of the Zn(II) complex was confirmed facilely by HRMS spectra, 1H NMR spectra and elemental analysis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Circular Dichroism
  • Cyclams
  • Heterocyclic Compounds / chemistry*
  • Organometallic Compounds / chemical synthesis*
  • Organometallic Compounds / chemistry
  • Peptide Nucleic Acids / chemical synthesis*
  • Peptide Nucleic Acids / chemistry
  • Stereoisomerism
  • Uracil / chemistry
  • Zinc / chemistry*

Substances

  • Cyclams
  • Heterocyclic Compounds
  • Organometallic Compounds
  • Peptide Nucleic Acids
  • Uracil
  • cyclen
  • Zinc