Studies on the products of conversion of 4-ethoxycarbonylmethyl-1,2,4-triazoline-5-thione. VII. Synthesis of 4-beta-acetylaminoethyl derivatives of 1,2,4-triazoline-5-thione

Acta Pol Pharm. 1992;49(4):73-6.

Abstract

In the reaction of 4-ethoxycarbonylmethyl-1,2,4-triazoline-5-thione derivatives (Ia,b) with the primary amines the corresponding amides (IIa,b-IVa,b) have been formed. These amides were then undergone to reduction with LiAlH4 leading to the formation of corresponding amines (Va,b-VIIa,b). Then by means of the reaction with acetic anhydride these amines were transformed into corresponding acetylamine derivatives of 1,2,4-triazoline-5-thione (VIIIa,b-Xa,b).

MeSH terms

  • Acetic Anhydrides / chemistry
  • Acetylation
  • Amines / chemistry*
  • Chemical Phenomena
  • Chemistry, Physical
  • Thioamides / chemistry
  • Thiones / chemistry*
  • Triazoles / chemistry*

Substances

  • Acetic Anhydrides
  • Amines
  • Thioamides
  • Thiones
  • Triazoles
  • 1,2,4-triazole
  • acetic anhydride