MicroRNAs: Loquacious speaks out

Philipp J F Leuschner; Gregor Obernosterer; Javier Martinez

doi:10.1016/j.cub.2005.07.044

MicroRNAs: Loquacious speaks out

Curr Biol. 2005 Aug 9;15(15):R603-5. doi: 10.1016/j.cub.2005.07.044.

Authors

Philipp J F Leuschner¹, Gregor Obernosterer, Javier Martinez

Affiliation

¹ Institute of Molecular Biotechnology of the Austrian Academy of Sciences, IMBA, Vienna, Austria.

PMID: 16085484
DOI: 10.1016/j.cub.2005.07.044

Abstract

In Drosophila, Dicer-2 requires the double-stranded RNA binding protein R2D2, to mediate the assembly of short interfering RNAs into the RNA-induced silencing complex. New data show that Dicer-1 also requires a double-stranded RNA binding protein called Loquacious for efficient microRNA-mediated gene silencing.

Publication types

Review

MeSH terms

Animals
Drosophila
Drosophila Proteins / metabolism*
Gene Silencing / physiology*
Models, Genetic*
RNA Helicases / metabolism*
RNA, Small Interfering / genetics
RNA, Small Interfering / metabolism*
RNA-Binding Proteins / genetics
RNA-Binding Proteins / metabolism*
RNA-Induced Silencing Complex / genetics
RNA-Induced Silencing Complex / metabolism*
Ribonuclease III / metabolism

Substances

Drosophila Proteins
RNA, Small Interfering
RNA-Binding Proteins
RNA-Induced Silencing Complex
DCR-2 protein, Drosophila
Ribonuclease III
RNA Helicases