Techniques and instrumentation are now widely available that enable interventional MR-guided preoperative needle localization and lesion marking. Minimally invasive MR-guided core biopsy techniques have been demonstrated but remain limited for small lesions and will be facilitated by the development of biopsy instruments that can be directly visualized using MR imaging. MR-guided tumor ablation is beginning to be evaluated in a few centers. It holds promise as new treatment modality in the continuing trend toward greater breast conservation in the local therapy of breast cancer. Further studies are needed to document the ability of MR-guided ablation to control the margins of a tumor as effectively as surgery. Patients with an extensive in situ intra-ductal component may pose a significant hurdle because the extent of ductal carcinoma in situ maybe underestimated on breast MR images. Ultimately, the success of MR-guided thermal ablation depends on the ability of MR imaging to map the extent of heating during the procedure so that the procedure can be performed to achieve complete control of the tumor margins. It is unfortunate that the conventional method for MR thermometry--the proton resonance frequency shift method--does not work in fat or in voxels with a mix of fat and glandular tissue and, hence, has limited applicability in the breast. Other methods, including measurement of T1 and T2, are being investigated as alternatives.