Lentigo maligna. Cytogenetic, ultrastructural, and phenotypic characterization of a primary cell culture

Cancer Genet Cytogenet. 1992 Jun;60(2):141-6. doi: 10.1016/0165-4608(92)90006-t.

Abstract

Lentigo maligna is an early cutaneous neoplastic lesion. This article presents the cytogenetic, ultrastructural, and phenotypic characterization of a primary cell culture obtained from a patient affected with lentigo maligna. Two cellular clones were identified, both characterized by chromosomal markers involving chromosome 10 with a breakpoint at 10q26.

Publication types

  • Case Reports

MeSH terms

  • Chromosome Deletion*
  • Chromosomes, Human, Pair 10*
  • Fluorescent Antibody Technique
  • Humans
  • Lentigo / genetics*
  • Lentigo / pathology
  • Male
  • Melanocytes / pathology
  • Melanoma / genetics*
  • Melanoma / pathology
  • Microscopy, Electron
  • Middle Aged
  • Skin Neoplasms / genetics*
  • Skin Neoplasms / pathology
  • Translocation, Genetic / genetics*
  • Tumor Cells, Cultured
  • Vimentin / analysis

Substances

  • Vimentin