Abstract
The phosphoinositide-3-OH-kinase-related kinases (PIKKs) are atypical protein kinases exclusive to eukaryotes. They mediate the cellular response to a range of stresses, including genome and RNA surveillance and availability of nutrients for growth. Orthologues of five out of the six PIKK family members are present in plant genomes. Recent studies in plant PIKKs have revealed features unique to, and in common with, other PIKKs. This review summarizes the basic knowledge of these proteins in mammals and yeast in comparison with what is known for Arabidopsis and other plants.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adaptor Proteins, Signal Transducing
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Amino Acid Sequence
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Animals
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Arabidopsis / enzymology*
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Arabidopsis Proteins / chemistry
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Arabidopsis Proteins / metabolism
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Ataxia Telangiectasia Mutated Proteins
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Cell Cycle Proteins / metabolism
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Gene Expression Regulation, Plant
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Genes, Plant
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Genome, Plant
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Models, Biological
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Molecular Sequence Data
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Nuclear Proteins / metabolism
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Phosphatidylinositol 3-Kinases / chemistry*
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Plant Proteins / metabolism
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Protein Kinases / metabolism
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Protein Serine-Threonine Kinases / metabolism
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Protein Structure, Tertiary
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RNA / chemistry
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Sequence Homology, Amino Acid
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Signal Transduction
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TOR Serine-Threonine Kinases
Substances
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ATM protein, Arabidopsis
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Adaptor Proteins, Signal Transducing
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Arabidopsis Proteins
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Cell Cycle Proteins
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Nuclear Proteins
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Plant Proteins
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transformation-transcription domain-associated protein
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RNA
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Protein Kinases
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ATR protein, Arabidopsis
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Ataxia Telangiectasia Mutated Proteins
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Protein Serine-Threonine Kinases
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TOR Serine-Threonine Kinases