[Electroencephalography measures in motor skill learning and effects of bromazepam]

Arq Neuropsiquiatr. 2005 Jun;63(2B):443-51. doi: 10.1590/s0004-282x2005000300015. Epub 2005 Jul 25.
[Article in Portuguese]

Abstract

Neuromodulators change brain's neural circuitry. Bromazepam is often been used in the pharmacological treatment of anxiety disorders. Few papers links this anxiolytic to motor tasks. The purpose of this study was to examine motor and electrophysiological changes produced by administration of bromazepam in differents doses (3 and 6 mg). The sample consisted of 39 healthy individuals, of both sexes, between 20 and 30 years of age. The control (placebo) and experimental (bromazepam 3mg and bromazepam 6 mg) groups were submitted to a typewriting task, in a randomized, double-blind design. The results did not reveal differences on score and time of the attention test. In the comportamental analysis was noticed blocks as main effect to behavioral variables (time and mistakes in the task). Electrophysiological data showed significants interactions to: laterally/condition/moment; laterally/condition; laterally/moment; condition/moment; condition/site.

Publication types

  • English Abstract
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Analysis of Variance
  • Anti-Anxiety Agents / administration & dosage
  • Anti-Anxiety Agents / pharmacology*
  • Bromazepam / administration & dosage
  • Bromazepam / pharmacology*
  • Double-Blind Method
  • Electroencephalography*
  • Female
  • Functional Laterality
  • Hand / physiology
  • Humans
  • Learning / drug effects*
  • Learning / physiology
  • Male
  • Motor Skills / drug effects*
  • Motor Skills / physiology

Substances

  • Anti-Anxiety Agents
  • Bromazepam