MPO-ANCA-associated pseudovasculitis in cardiac myxoma

Eur J Neurol. 2005 Aug;12(8):619-20. doi: 10.1111/j.1468-1331.2005.01042.x.

Abstract

We describe a case of cardiac myxoma whose clinical presentation mimicked that of polyarteritis nodosa. The serum levels of MPO-ANCA and IL-6 were elevated on laboratory investigation and normalized after the removal of the tumor. We suggest that a 'true' vasculitic mechanism contributes to the pathogenesis of pseudovasculitis in cardiac myxoma.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antibodies, Antineutrophil Cytoplasmic / metabolism*
  • Autoantibodies / analysis
  • Granulocyte Colony-Stimulating Factor
  • Heart Neoplasms / immunology*
  • Heart Neoplasms / physiopathology
  • Hematopoietic Cell Growth Factors / metabolism*
  • Humans
  • Interleukin-3
  • Interleukin-6 / metabolism*
  • Male
  • Monocytes / pathology
  • Myxoma / immunology*
  • Myxoma / physiopathology
  • Neutrophils / pathology
  • Peroxidase / immunology*
  • Recombinant Fusion Proteins / metabolism*
  • Recombinant Proteins
  • Vasculitis / diagnosis*
  • Vasculitis / etiology

Substances

  • Antibodies, Antineutrophil Cytoplasmic
  • Autoantibodies
  • Hematopoietic Cell Growth Factors
  • Interleukin-3
  • Interleukin-6
  • Recombinant Fusion Proteins
  • Recombinant Proteins
  • myelopoietin
  • Granulocyte Colony-Stimulating Factor
  • Peroxidase