Abstract
High occurrence of the non-macrolide-lincosamide-streptogramin B resistance genes msrA (53%) and linA/linA' (30%) was found among 98 methicillin-resistant coagulase-negative staphylococci additionally resistant to macrolides and/or lincosamides. The gene msrA predominated in Staphylococcus haemolyticus (43 of 62 isolates). In Staphylococcus epidermidis, it was present in 7 of 27 isolates. A novel mechanism of resistance to lincosamides appears to be present in 10 genetically related isolates of S. haemolyticus in the absence of ermA, ermC, msrA, and linA/linA'.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Bacterial Proteins / genetics
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Coagulase / metabolism
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Czech Republic / epidemiology
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Drug Resistance, Bacterial* / genetics
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Humans
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Incidence
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Lincosamides
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Macrolides / pharmacology*
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Membrane Transport Proteins / genetics
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Methicillin Resistance*
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Microbial Sensitivity Tests
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Staphylococcus / classification
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Staphylococcus / drug effects*
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Staphylococcus / enzymology
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Staphylococcus / genetics
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Coagulase
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Lincosamides
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Macrolides
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Membrane Transport Proteins
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msrA protein, Staphylococcus epidermidis