Abstract
Vagus nerve stimulation (VNS) is an effective adjunctive treatment for intractable epilepsy. However, the optimal range of device duty-cycles [on/(on + off times)] is poorly understood. The authors performed a multicenter, randomized trial of three unique modes of VNS, which varied primarily by duty-cycle. The results indicate that the three duty-cycles were equally effective. The data support the use of standard duty-cycles as initial therapy.
Publication types
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Comparative Study
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Multicenter Study
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Cough / etiology
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Electric Stimulation Therapy / adverse effects
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Electric Stimulation Therapy / methods*
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Electric Stimulation Therapy / trends
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Electrodes
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Epilepsy / physiopathology
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Epilepsy / therapy*
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Gastrointestinal Diseases / etiology
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Humans
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Pharyngitis / etiology
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Prospective Studies
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Treatment Outcome
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Vagus Nerve / physiology*
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Vagus Nerve / surgery
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Voice Disorders / etiology