Abstract
New derivatives related to floctafenine were synthesized and representative examples were screened for their anti-inflammatory and analgesic activities. All compounds tested were found to exhibit anti-inflammatory and analgesic activities and some were more potent than the references, floctafenine and indomethacin, in carragenan-induced rat's paw edema. None of the tested compounds showed an ulcerogenic effect on the p-benzoquinone-induced writhing test in mice.
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / adverse effects
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Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*
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Anti-Inflammatory Agents, Non-Steroidal / chemistry
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Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
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Edema / drug therapy
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Female
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Male
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Mice
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Molecular Structure
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Pain / drug therapy
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Pain Measurement
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Rats
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Structure-Activity Relationship
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ortho-Aminobenzoates / adverse effects
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ortho-Aminobenzoates / chemical synthesis*
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ortho-Aminobenzoates / chemistry
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ortho-Aminobenzoates / therapeutic use
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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ortho-Aminobenzoates
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floctafenine