Investigation of oxidative stress defenses of Neisseria gonorrhoeae by using a human polymorphonuclear leukocyte survival assay

Infect Immun. 2005 Aug;73(8):5269-72. doi: 10.1128/IAI.73.8.5269-5272.2005.

Abstract

Neisseria gonorrhoeae has well-characterized oxidative stress defense systems that protect against oxidative killing in in vitro assays. In contrast, mutant strains of N. gonorrhoeae lacking oxidative stress defenses are identical to the wild type when tested in an ex vivo survival assay using human polymorphonuclear leukocytes.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Biological Assay
  • Cell Survival
  • Gonorrhea / metabolism*
  • Humans
  • Mutation
  • Neisseria gonorrhoeae / genetics
  • Neisseria gonorrhoeae / metabolism*
  • Neutrophils / metabolism*
  • Neutrophils / microbiology*
  • Oxidative Stress / genetics
  • Oxidative Stress / physiology*