Synthesis and biological activity of novel acridinylidene and benzylidene thiazolidinediones

R H Mourão; T G Silva; A L M Soares; E S Vieira; J N Santos; M C A Lima; V L M Lima; S L Galdino; J Barbe; I R Pitta

doi:10.1016/j.ejmech.2005.06.002

Synthesis and biological activity of novel acridinylidene and benzylidene thiazolidinediones

Eur J Med Chem. 2005 Nov;40(11):1129-33. doi: 10.1016/j.ejmech.2005.06.002. Epub 2005 Aug 29.

Authors

R H Mourão¹, T G Silva, A L M Soares, E S Vieira, J N Santos, M C A Lima, V L M Lima, S L Galdino, J Barbe, I R Pitta

Affiliation

¹ Departamento de Antibioticos, Universidade Federal de Pernambuco, Centro de Ciências Biológicas, 50670-901 Recife, Brasil.

PMID: 16040159
DOI: 10.1016/j.ejmech.2005.06.002

Abstract

A novel set of acridinylidene thiazolidinediones and benzylidene thiazolidinediones was synthesized by nucleophilic addition of cyanoacrylates. Some of these compounds were evaluated for their glucose lowering capability and their effects on the triglyceride level in alloxan diabetic mice.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Acridines / chemical synthesis*
Acridines / chemistry
Acridines / pharmacology
Animals
Benzyl Compounds / chemical synthesis*
Benzyl Compounds / chemistry
Benzyl Compounds / pharmacology
Blood Glucose / drug effects
Body Weight / drug effects
Diabetes Mellitus, Experimental / blood
Diabetes Mellitus, Experimental / mortality
Drug Evaluation, Preclinical
Female
Hypoglycemic Agents / chemical synthesis*
Hypoglycemic Agents / pharmacology
Male
Mice
Rosiglitazone
Thiazolidinediones / chemical synthesis*
Thiazolidinediones / chemistry
Thiazolidinediones / pharmacology
Triglycerides / blood

Substances

3-benzyl-5-acridinylidene-thiazolidine-2,4-dione
5-benzylidene-3-(4-methyl-benzyl)-thiazolidine-2,4-dione
Acridines
Benzyl Compounds
Blood Glucose
Hypoglycemic Agents
Thiazolidinediones
Triglycerides
Rosiglitazone