No evidence of plasticity in hair follicles of recipients after allogeneic hematopoietic stem cell transplantation

Alicia Rovó; Sandrine Meyer-Monard; Dominik Heim; Caroline Arber; Jakob R Passweg; Alois Gratwohl; André Tichelli

doi:10.1016/j.exphem.2005.04.010

No evidence of plasticity in hair follicles of recipients after allogeneic hematopoietic stem cell transplantation

Exp Hematol. 2005 Aug;33(8):909-11. doi: 10.1016/j.exphem.2005.04.010.

Authors

Alicia Rovó¹, Sandrine Meyer-Monard, Dominik Heim, Caroline Arber, Jakob R Passweg, Alois Gratwohl, André Tichelli

Affiliation

¹ Division of Hematology, University Hospital Basel, Basel, Switzerland. aliciarovo@bluewin.ch

PMID: 16038783
DOI: 10.1016/j.exphem.2005.04.010

Abstract

Here we show in a prospective quantitative study of 115 patients after allogeneic hematopoietic stem cell transplantation that hair follicles remain exclusively of recipient type despite full whole blood donor-type chimerism. Our data indicate that unmanipulated hematopoietic donor stem cells do not contribute directly to reconstitution even in an organ at highest need for repair.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Child
Female
Hair Follicle / cytology
Hair Follicle / physiology*
Hematopoietic Stem Cell Transplantation*
Humans
Male
Middle Aged
Prospective Studies
Regeneration / physiology*
Transplantation Chimera / physiology*