Phenanthroindolizidine alkaloids from the stems of Ficus septica

J Nat Prod. 2005 Jul;68(7):1071-5. doi: 10.1021/np050095o.

Abstract

In addition to six known phenanthroindolizidine alkaloids, eight new alkaloids, namely, ficuseptines B-D (1-3), 10R,13aR-tylophorine N-oxide (4), 10R,13aR-tylocrebrine N-oxide (5), 10S,13aR-tylocrebrine N-oxide (6), 10S,13aR-isotylocrebrine N-oxide (7), and 10S,13aS-isotylocrebrine N-oxide (8), were isolated from a methanol extract of the stems of Ficus septica. The structures of the new compounds were elucidated by means of spectroscopic data interpretation. Cytotoxicity of some of these alkaloids was assessed in vitro using the HONE-1 and NUGC cell lines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemistry
  • Alkaloids / isolation & purification*
  • Alkaloids / pharmacology
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Drug Screening Assays, Antitumor
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / isolation & purification*
  • Drugs, Chinese Herbal / pharmacology
  • Ficus / chemistry*
  • Humans
  • Indolizines / chemistry
  • Indolizines / isolation & purification*
  • Indolizines / pharmacology
  • Molecular Structure
  • Phenanthrenes / chemistry
  • Phenanthrenes / isolation & purification*
  • Phenanthrenes / pharmacology
  • Plant Stems / chemistry
  • Plants, Medicinal / chemistry*
  • Tumor Cells, Cultured

Substances

  • Alkaloids
  • Antineoplastic Agents, Phytogenic
  • Drugs, Chinese Herbal
  • Indolizines
  • Phenanthrenes
  • ficuseptine B
  • ficuseptine C
  • ficuseptine D