5'-Homoneplanocin A inhibits hepatitis B and hepatitis C

J Med Chem. 2005 Jul 28;48(15):5043-6. doi: 10.1021/jm058200e.

Abstract

As an outgrowth of our program to develop an efficient synthesis of 5'-homoneplanocin A, its antiviral potential was explored beyond that already in the literature. From that, this compound was found to have meaningful activity toward hepatitis B and hepatitis C, which represents an example of one agent effective toward both viruses. These data and an improved preparation of 5'-homoneplanocin A are reported.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenosine / analogs & derivatives*
  • Adenosine / chemical synthesis
  • Adenosine / chemistry
  • Adenosine / pharmacology*
  • Antiviral Agents / chemical synthesis
  • Antiviral Agents / chemistry
  • Antiviral Agents / pharmacology*
  • Cell Line
  • Hepacivirus / drug effects*
  • Hepacivirus / physiology
  • Hepatitis B virus / drug effects*
  • Hepatitis B virus / physiology
  • Humans
  • Stereoisomerism
  • Virus Replication / drug effects

Substances

  • 5'-homoneplanocin
  • Antiviral Agents
  • Adenosine