Effect of propofol anesthesia on pallidal neuronal discharges in generalized dystonia

F Steigerwald; L Hinz; M O Pinsker; J Herzog; R U Stiller; F Kopper; H M Mehdorn; G Deuschl; J Volkmann

doi:10.1016/j.neulet.2005.06.012

Effect of propofol anesthesia on pallidal neuronal discharges in generalized dystonia

Neurosci Lett. 2005 Oct 7;386(3):156-9. doi: 10.1016/j.neulet.2005.06.012.

Authors

F Steigerwald¹, L Hinz, M O Pinsker, J Herzog, R U Stiller, F Kopper, H M Mehdorn, G Deuschl, J Volkmann

Affiliation

¹ Department of Neurology, Christian-Albrechts-University, Schittenhelmstr. 10, D-24105 Kiel, Germany.

PMID: 16024174
DOI: 10.1016/j.neulet.2005.06.012

Abstract

We present the results of continuous microelectrode recordings from individual pallidal neurons in patients with idiopathic torsion dystonia under different levels of propofol anesthesia. Neither the estimated plasma concentration of propofol nor the level of consciousness had a consistent effect on abnormally low neuronal firing rates. Our data support the pathophysiological model of a decreased basal ganglia output in dystonia and argue against a possible pharmacological artifact.

MeSH terms

Action Potentials / drug effects*
Action Potentials / physiology
Adolescent
Adult
Anesthetics, Intravenous / blood
Anesthetics, Intravenous / pharmacology
Artifacts
Consciousness / drug effects
Consciousness / physiology
Dystonia Musculorum Deformans / physiopathology*
Electrodiagnosis / methods
Electrophysiology / methods
Globus Pallidus / drug effects*
Globus Pallidus / physiopathology*
Humans
Microelectrodes
Middle Aged
Neural Inhibition / drug effects
Neural Inhibition / physiology
Neurons / drug effects*
Neurons / physiology
Propofol / blood
Propofol / pharmacology*

Substances

Anesthetics, Intravenous
Propofol